Health-related quality of life as an endpoint in oncology phase I trials: a systematic review
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چکیده
منابع مشابه
Quality of life as an endpoint in Phase I oncology clinical trials of novel chemotherapy drugs.
This paper examines the rationale, utility and feasibility of including quality of life as an outcome measure in Phase I trials of new applications of chemotherapy drugs. Typically, Phase I trials in oncology are designed to assess safety and maximal tolerated dose; however, it is argued that when subjectively assessed, self perceived quality of life is as important as physical toxicity. The ou...
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Considering the burden of epilepsy on society, investigation of the health-related quality of life (HRQoL) is essential for the better future targeting, optimization of current interventions and managing strategies for epilepsy. Nineteen HRQoL were investigated in this review. Increases in seizure incidence, level of depression and seizure severity were significantly related to reduced HRQoL. T...
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BACKGROUND AND AIM: Oral health-related quality of life (OHRQoL) is a practically new but rapidly growing approach. The concept of OHRQoL can become a tool to explain and shape the state of clinical practice. This study was aimed to do a systematic review about the impacts of different dental treatments on OHRQoL. METHODS:</strong...
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Background: Behcet’s disease is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet’s disease. Methods: A total of 13 articles were extracted from four main databases including PubMed, ...
متن کاملThe measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review
BACKGROUND The goal of much care in chronic childhood illness is to improve quality of life (QOL). However, surveys suggest QOL measures are not routinely included. In addition, there is little consensus about the quality of many QOL measures. OBJECTIVES To determine the extent to which quality of life (QOL) measures are used in paediatric clinical trials and evaluate the quality of measures ...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2019
ISSN: 1471-2407
DOI: 10.1186/s12885-019-5579-3